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阻害剤 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK
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シグナル伝達経路 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル
DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK 膜輸送体・イオンチャネル
代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
幹細胞 チロシンキナーゼ・アダプター ユビキチン その他 PROTAC
生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー
天然化合物ライブラリー HTS用天然物ライブラリー 分野別 天然化合物ライブラリー 天然物誘導体ライブラリー CADD用天然物ライブラリー
ドラッグライク 化合物ライブラリー ドラッグライクライブラリー
フラグメントライブラリー ゼネラルフラグメントライブラリー 特徴的なフラグメントライブラリー カスタム化合物ライブラリー
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

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Search Results for " Na /K ATPase "

ターゲット

ATPase Platelet aggregation

33

阻害剤

23

天然化合物

4

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T0712 Suloctidil ATPase , Platelet aggregation
Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred.
T6443 Chloroprocaine hydrochloride Chloroprocaine HCl ATPase , Others
Chloroprocaine hydrochloride (Chloroprocaine HCl) is a local anesthetic during surgical procedures.
T0490 Chlorpropamide Diabinese ATPase , ABC
Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
T6953 Prilocaine Citanest,Propitocaine,NSC 40027 ATPase , Sodium Channel
Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
T0796 Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest ATPase , Sodium Channel
Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.
T2176 2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime Akt
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.
T2621 Rostafuroxin PST 2238 ATPase , RSV
Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.
T14052 5-IAF 5-Iodoacetamidofluorescein
5-IAF is a fluorescein derivative of indoleacetamide, a fluorescent probe that can be used to label proteins and others containing free thiols (cysteine side chains). 5-IAF can label the catalytic (alpha) subunit of dog ...
TP1033L Transdermal Peptide Disulfide Acetate TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base) ATPase
Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide...
T15600 Istaroxime PST2744 Others
Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).
T15599 Istaroxime hydrochloride PST2744 hydrochloride Others
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
T68916 ASI-254
ASI-254 is an aminosugar cardiac glycoside and an inhibitor of Na+,K+ -ATPase.
T36060 Digoxigenin Monodigitoxoside
Digoxigenin monodigitoxoside is a cardiac glycoside metabolite of digoxin and a Na+/K+ ATPase inhibitor.
T35923 Caloxin 2A1 TFA
Caloxin 2A1 TFA is a peptide inhibitor specifically targeting the extracellular plasma membrane Ca2+-ATPase (PMCA), without influencing the basal activities of Mg2+-ATPase or Na+-K+-ATPase[1].
T75280 Prilocaine acetate
Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].
T78564 Depramine GP 31406
Depramine (GP 31406), a tricyclic antidepressant, exhibits pharmacological activity by inhibiting acetylcholinesterase, Mg^2+-ATPase, and Na^+/K^+ ATPase activity [1] [2].
T76374 SPAI-1
SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [...
T40437 Caloxin 2A1
Caloxin 2A1 is an inhibitor peptide of the plasma membrane Ca 2+-ATPase (PMCA) responsible for extracellular signaling. Importantly, Caloxin 2A1 has no impact on the basal Mg 2+-ATPase or Na+-K+-ATPase activities.
T71806 Tenellin
Tenellin is a fungal metabolite that inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in erythrocytes. Tenellin is cytotoxic to Sf9 and Sf21 insect cells.
T72812 (R)-Tegoprazan
(R)-Tegoprazan, a benzimidazole derivative, serves as a potent inhibitor of kidney H+/K+-ATPase, demonstrating significant efficacy with an IC50 of 98 nM against canine kidney Na+/K+-ATPase. This compound shows promise f...
T37707 14-Anhydrodigitoxigenin
14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.1 It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 μM.2
T60469 Chloroprocaine
Chloroprocaine (2-Chloroprocaine) is an effective Na,K-ATPase activity inhibitor with an IC 50 of 13 mM. Chloroprocaine is a local anesthetics that block peripheral nerve [1].
T37766 Transdermal Peptide (TD 1 (peptide))
Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules. Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts ...
T75360 Oxonol VI
Oxonol VI serves as an optical indicator for membrane potentials within lipid vesicles and is effective in identifying variations in membrane potential linked to the activity of the (Na + + K +)-ATPase in reconstituted v...
T69975 Istaroxime oxalate
Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular...
T37767 Transdermal Peptide Disulfide TFA
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA), an 11-amino acid peptide, specifically binds to the Na+/K+-ATPase beta-subunit (ATP1B1), predominantly interacting with its C-terminus. This compound is ca...
TP1032 Transdermal Peptide TFA (918629-48-8 free base) Transdermal Peptide TFA,TD 1 (peptide) (TFA)
Transdermal Peptide TFA (TD 1 Peptide TFA) is an 11-amino acid polypeptide that binds to Na+/K+ -atpase beta-subunit (ATP1B1) and interacts with the C terminal of ATP1B1.Transdermal Peptide TFA can enhance the transmissi...
T71122 Carsatrin (free base)
Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle...
T70975 Carsatrin succinate
Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action ...
T38151 Germicidin A
Germicidin A is a pyranone originally derived from S. viridochromogenes that acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as...
T68808 11-Dehydrocorticosterone
11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration...
T70428 Nepaprazole sodium
Nepaprazole Na is the salt form of Nepaprazole Free Base, also known as TY-11345, is a proton pump inhibitor potentially for treatment of gastric ulcer. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated ra...
T36659 Boromycin
Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affectin...

Compounds

Suloctidil
T0712
Synonym:
Target: ATPase, Platelet aggregation
Chloroprocaine hydrochloride
T6443
Synonym: Chloroprocaine HCl
Target: ATPase, Others
Chlorpropamide
T0490
Synonym: Diabinese
Target: ATPase, ABC
Prilocaine
T6953
Synonym: Citanest,Propitocaine,NSC 40027
Target: ATPase, Sodium Channel
Prilocaine hydrochloride
T0796
Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest
Target: ATPase, Sodium Channel
2,3-Butanedione 2-Monoxime
T2176
Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime
Target: Akt
Rostafuroxin
T2621
Synonym: PST 2238
Target: ATPase, RSV
5-IAF
T14052
Synonym: 5-Iodoacetamidofluorescein
Target:
Transdermal Peptide Disulfide Acetate
TP1033L
Synonym: TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)
Target: ATPase
Istaroxime
T15600
Synonym: PST2744
Target: Others
Istaroxime hydrochloride
T15599
Synonym: PST2744 hydrochloride
Target: Others
ASI-254
T68916
Synonym:
Target:
Digoxigenin Monodigitoxoside
T36060
Synonym:
Target:
Caloxin 2A1 TFA
T35923
Synonym:
Target:
Prilocaine acetate
T75280
Synonym:
Target:
Depramine
T78564
Synonym: GP 31406
Target:
SPAI-1
T76374
Synonym:
Target:
Caloxin 2A1
T40437
Synonym:
Target:
Tenellin
T71806
Synonym:
Target:
(R)-Tegoprazan
T72812
Synonym:
Target:
14-Anhydrodigitoxigenin
T37707
Synonym:
Target:
Chloroprocaine
T60469
Synonym:
Target:
Transdermal Peptide (TD 1 (peptide))
T37766
Synonym:
Target:
Oxonol VI
T75360
Synonym:
Target:
Istaroxime oxalate
T69975
Synonym:
Target:
Transdermal Peptide Disulfide TFA
T37767
Synonym:
Target:
Transdermal Peptide TFA (918629-48-8 free base)
TP1032
Synonym: Transdermal Peptide TFA,TD 1 (peptide) (TFA)
Target:
Carsatrin (free base)
T71122
Synonym:
Target:
Carsatrin succinate
T70975
Synonym:
Target:
Germicidin A
T38151
Synonym:
Target:
11-Dehydrocorticosterone
T68808
Synonym:
Target:
Nepaprazole sodium
T70428
Synonym:
Target:
Boromycin
T36659
Synonym:
Target:
カタログ番号 製品名 別名 ターゲット
T1719 Bufalin ATPase
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potenti...
TJP2872 Acevaltrate Acevaltratum,Acetoxyvaltrate ATPase , Others
1. Acevaltrate (Acevaltratum) displays high cytotoxicity against GLC(4), a human small-cell lung cancer cell line, and against COLO 320, a human colorectal cancer cell line, with IC50 values of 1-6 uM.
T0295 Digitoxin Digitoxoside,Unidigin,Digitoxinum ATPase , Others
Digitoxin (Digitoxinum) is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM).
T5S0890 Oleandrin Neriostene,Folinerin,Foliandrin Apoptosis , ATPase , Potassium Channel , Sodium Channel
1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ...
TN5073 Strophanthidin Strophanthidine ATPase , Calcium Channel
Strophanthidin (Strophanthidine) can induce calcium overload in vivo.
T2922 Phlorizin Floridzin,NSC 2833,Phloridzin ATPase , SGLT
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
T8183 Deslanoside Desacetyllanatoside C,Deacetyllanatoside C ATPase , Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane p...
T2O2668 Oleic acid Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid Apoptosis , ATPase , Others , Endogenous Metabolite
Oleic acid (Glycon Wo) is a natural product, a common saturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator.
T2822 Ginsenoside Rb1 Gypenoside Ⅲ,Gypenoside III ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T3432 Cinobufagin Cinobufagine Apoptosis , ATPase , Autophagy
Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.
T36390 Sodium oleate Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt ATPase
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator.
T4973 Paraxanthine 1,7-DIMETHYLXANTHINE Endogenous Metabolite
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...
T6S1049 Wilforine ATPase
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi...
T7190 Actein Apoptosis , Akt , JNK , Autophagy
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...
T5S1982 Periplocin Periplocoside Apoptosis , Others
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato...
T13618 Citreoviridin Others
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-depen...
TN6631 Chamigrenol
Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL.
TN5141 Thevetin B ATPase , Potassium Channel , Sodium Channel
Thevetin B is a cardiac glycoside and an inhibitor of Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) from Thevetia peruviana.
TN4697 Odoroside H ATPase , Potassium Channel , Sodium Channel
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
TN2306 Wilfordine ATPase , Potassium Channel , Sodium Channel
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN5060 Stauntosaponin A ATPase , Potassium Channel , Sodium Channel
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
T38069 Aquastatin A
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC...
T35779 Oosporein
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectiv...

天然物製品

Bufalin
T1719
Synonym:
Target: ATPase
Acevaltrate
TJP2872
Synonym: Acevaltratum,Acetoxyvaltrate
Target: ATPase, Others
Digitoxin
T0295
Synonym: Digitoxoside,Unidigin,Digitoxinum
Target: ATPase, Others
Oleandrin
T5S0890
Synonym: Neriostene,Folinerin,Foliandrin
Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel
Strophanthidin
TN5073
Synonym: Strophanthidine
Target: ATPase, Calcium Channel
Phlorizin
T2922
Synonym: Floridzin,NSC 2833,Phloridzin
Target: ATPase, SGLT
Deslanoside
T8183
Synonym: Desacetyllanatoside C,Deacetyllanatoside C
Target: ATPase, Drug Metabolite
Oleic acid
T2O2668
Synonym: Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid
Target: Apoptosis, ATPase, Others, Endogenous Metabolite
Ginsenoside Rb1
T2822
Synonym: Gypenoside Ⅲ,Gypenoside III
Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV
Cinobufagin
T3432
Synonym: Cinobufagine
Target: Apoptosis, ATPase, Autophagy
Sodium oleate
T36390
Synonym: Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt
Target: ATPase
Paraxanthine
T4973
Synonym: 1,7-DIMETHYLXANTHINE
Target: Endogenous Metabolite
Wilforine
T6S1049
Synonym:
Target: ATPase
Actein
T7190
Synonym:
Target: Apoptosis, Akt, JNK, Autophagy
Periplocin
T5S1982
Synonym: Periplocoside
Target: Apoptosis, Others
Citreoviridin
T13618
Synonym:
Target: Others
Chamigrenol
TN6631
Synonym:
Target:
Thevetin B
TN5141
Synonym:
Target: ATPase, Potassium Channel, Sodium Channel
Odoroside H
TN4697
Synonym:
Target: ATPase, Potassium Channel, Sodium Channel
Wilfordine
TN2306
Synonym:
Target: ATPase, Potassium Channel, Sodium Channel
Stauntosaponin A
TN5060
Synonym:
Target: ATPase, Potassium Channel, Sodium Channel
Aquastatin A
T38069
Synonym:
Target:
Oosporein
T35779
Synonym:
Target:

Recombinant Proteins

Species：
Human (4)
Expression System：
E. coli (2)
HEK293 (2)
Tag：
His (3)
N-terminal 6xHis-SUMO-tagged (1)
カタログ番号 製品名 Species Expression System
TMPY-06599 ATP1B4 Protein, Human, Recombinant (His) Human E. coli
ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However...
TMPY-03788 ATP1B1 Protein, Human, Recombinant (His) Human HEK293
ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for es...
TMPY-04927 ATP1B2 Protein, Human, Recombinant (His) Human HEK293
ATP1B2 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 27.7 kDa. Accession number: P14415
TMPH-01358 FXYD3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus...
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